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Alzheimer's disease is characterized by the presence of two neuropathological lesions, senile plaques and neurofibrillary tangles.

Neurofibrillary tangles are composed of abnormal accumulation of hyperphosphorylated and aggregated tau proteins. The abundance of this lesion is highly correlated with cognitive deficits. 

Tau proteins in neurofibrillary tangles are aggregated and formed paired helical filaments. In the laboratory, we can isolate and observe these filaments by electron microscopy.

In the laboratory, we use several models for Alzheimer's disease from the cultured cells (Neuronal cultures, FREt cells) to the mice models to reproduce tau pathology found in neurofibrillary tangles and study the effect of treatments on the formation of this neuronal lesion.