PRINCIPAL INVESTIGATOR








 

LEROY Karelle

Karelle Leroy is particularly interested in understanding the mechanisms leading to the formation of brain lesions found in Alzheimer’s disease and other tauopathies. Karelle Leroy has a long expertise of more than 20 years in AD research. In addition to these research activities, Karelle Leroy holds histology courses for students in dental sciences, biomedical engineers and physiotherapists.

POSTDOCTORAL FELLOWS


Kunie Ando

Kunie Ando works on genetic risk factors implicated in Alzheimer’s disease and other tauopathies and 3D volume imaging in post-mortem brain tissues.


Siranjeevi Nagaraj

Nagaraj Siranjeevi works on the analysis of neuroprotective effects of miRNAs on the propagation of tau pathology.
PhD STUDENT


Emilie Doeraene



Emilie Doeraene analyzes the effect of metabolic disturbances found in diabetes on tau pathology.


Andreea Kosa

Andreea Kosa analyses the effect of tau ASOs administration on the development of tau pathology induced by mouse intracerebral injection of pathological tau proteins isolated from human AD brains.


Lidia Lopez Gutierrez

Lidia Lopez Gutierrez works on the implication of kinases (by reducing their expression with si-RNAs on tau pathology propagation in mouse models expressing murine or human tau seeded by pathological tau proteins from AD brain.

Carolina Quintanilla


Carolina Quintanilla analyses the effect of miRNAs on tau pathology propagation in cellular and mice models.

Emmanuel Aydin


Emmanuel Aydin tests the antidiabetic treatments as a new therapeutic strategy to reduce the risk of dementia.

UNIVERSITY PROFESSOR


Jean-Pierre Brion

Professor Jean-Pierre Brion discovered tau proteins as the components of neurofibrillary tangles in Alzheimer's disease. 

ALUMNI

Marie-Ange de Fisenne 

Marie-ange de Fisenne presented a thesis entitled "Analyse de la propagation de la pathologie tau dans le cerveau de modèles murins de la maladie d'Alzheimer après injections intravasculaires et intraoculaires de protéines tau pathologiques."

Her thesis work was published in two articles as first author :

de Fisenne MA, Yilmaz Z, De Decker R, Suain V, Buée L, Ando K, Brion JP, Leroy K. Alzheimer PHF-tau aggregates do not spread tau pathology to the brain via the Retino-tectal projection after intraocular injection in male mouse models. Neurobiol Dis. 2022

Houben S, de Fisenne MA, Ando K, Vanden Dries V, Poncelet L, Yilmaz Z, Mansour S, De Decker R, Brion JP, Leroy K. Intravenous Injection of PHF-Tau Proteins From Alzheimer Brain Exacerbates Neuroinflammation, Amyloid Beta, and Tau Pathologies in 5XFAD Trans