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Research
Hallmarks of Alzheimer's Disease in Stem-Cell-Derived Human Neurons Transplanted into Mouse Brain. Neuron. 2017 Mar 8;93(5):1066-1081.e8. doi: 10.1016/j.neuron.2017.02.001.
Picalm reduction exacerbates tau pathology in a murine tauopathy model. Acta Neuropathol. 2020 Apr;139(4):773-789. doi: 10.1007/s00401-020-02125-x.
Intravenous Injection of PHF-Tau Proteins From Alzheimer Brain Exacerbates Neuroinflammation, Amyloid Beta, and Tau Pathologies in 5XFAD Transgenic Mice. Front Mol Neurosci. 2020 Jul 14;13:106. doi: 10.3389/fnmol.2020.00106
de novo MAPT mutation G335A causes severe brain atrophy, 3R and 4R PHF-tau pathology and early onset frontotemporal dementia. Acta Neuropathol Commun. 2020 Jun 29;8(1):94. doi: 10.1186/s40478-020-00977-8.
Inositol trisphosphate 3-kinase B is increased in human Alzheimer brain and exacerbates mouse Alzheimer pathology. Brain. 2014 Feb;137(Pt 2):537-52. doi: 10.1093/brain/awt344. Epub 2014 Jan 8.
Increased level of active GSK-3beta in Alzheimer's disease and accumulation in argyrophilic grains and in neurones at different stages of neurofibrillary degeneration. Neuropathol Appl Neurobiol. 2007 Feb;33(1):43-55. doi: 10.1111/j.1365-2990.2006.00795.x.
de Fisenne MA, Yilmaz Z, De Decker R, Suain V, Buée L, Ando K, Brion JP, Leroy K. Alzheimer PHF-tau aggregates do not spread tau pathology to the brain via the Retino-tectal projection after intraocular injection in male mouse models. Neurobiol Dis. 2022
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https://alzheimer-research.medecine.ulb.be/navigation/funding